Protein Details: Amiloride-sensitive sodium channel subunit gamma
Protein ID
ICDB_Pro_0580
Protein Name
Amiloride-sensitive sodium channel subunit gamma
Gene Name
scnn1g-a
Organism
Xenopus laevis (African clawed frog)
Length
660 amino acids
AlphaFoldDB
AF-P51171-F1-model_v4.pdb
Function
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water; which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis; but also in airway surface liquid homeostasis; which is important for proper clearance of mucus.
Sequence
MSKSGKKLTQKLKKNLPVTGPQAPTLYELMQWYCLNTNTHGCRRIVVSKGRLRRWIWISLTLCAVAVIFWQCALLLMSYYSVSASITVTFQKLVYPAVTICNLNPYSYSKVKDRLAALEKETSQTLKNIYGFTEPLIRSKRDVGVNVENSTEDIFLKQIPLYRLESVKGSQLVVSDLKTKKRTRMSAKVIHRDAESVQDPGNMVGFKLCDPKNSSDCTIFTFSSGVNAIQEWYRLHYTNILAKISMEDKIAMGYKADELIVTCFFDGLSCDARNFTLFHHPLYGNCYTFNSAERGNLLVSSMGGAEYGLKVVLYIDEDEYNPYLSTAAGAKILVHDQDEYPFIEYLGTELETATETSIGMQLTESAKLSDPYSDCTMDGRDVSVENLYNKKYTLQICLNSCFQREMVRSCGCAHYDQPLPNGAKYCNYEEYPSWIYCYFKVYKQFVQEELGCQSACRESCSFKEWTLTRSLAKWPSLNSEEWMLRVLSWELGEKLNKNLTKNDLANLNIFYQDLNSRSISESPTYNIVTLLSNFGGQLGLWMSCSMICVLEIIEVFFIDSFWVVLRQRWRNWWENRKENQAEDTPEIPVPTMTGHDNPLCVDNPICLGEEDPPTFNSALQLPQSQDSHVPRTPPPKYNTLRIQSAFQLETIDSDEDVERL
PDB Structures
Ligand Binding
Binding Site
Disease
Location
DOI ID
10.1152/ajpcell.1995.269.1.c188
RefSeq
NP_001079123.1